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Home >> Antibodies >> Protein Tyrosine Phosphatase, non-receptor type 6

Protein Tyrosine Phosphatase, non-receptor type 6

Mouse Monoclonal Antibody [Clone CPTC-PTPN6-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified PTPN6 Mouse Monoclonal Antibody (CPTC-PTPN6-2). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

PTPN6; SHP1; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; 70 kda SHP-1L protein; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTPN6 / SHP

Positive Control

A431, Jurkat or K562 cell lysates; Lymph node or spleen.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, purchase antibody without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length PTPN6 protein

Cellular Localization

Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

65kDa

Specificity & Comments

PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Zhang, Q., et al. Proc. Natl. Acad. Sci. U.S.A. (2005)
  2. Kossev, P M, et al. The American Journal of Surgical Pathology, July 2001

Bioinformatics

  •  Entrez Gene ID: 5777
  •  Gene Symbol: PTPN6
  •  SwissProt: P29350
  •  Chromosome Location: 12p13.31
  •  Unigene: 63489
NBT02259