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Protein Tyrosine Phosphatase, non-receptor type 6 Antibody [PTPN6/7543]

Additional information

Catalog Number: 5777-MSM3
Host:

Reactivity:

Gene:

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In Stock
Catalog Number Formulation Size Price
5777-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5777-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5777-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Protein Tyrosine Phosphatase, non-receptor type 6 Antibody

Formalin-fixed, paraffin-embedded human spleen stained with PTPN6 Mouse Monoclonal Antibody (PTPN6/7543). Inset: PBS instead of primary antibody; secondary only negative control.

Protein Tyrosine Phosphatase, non-receptor type 6 Antibody - Image 2

Formalin-fixed, paraffin-embedded human spleen stained with PTPN6 Mouse Monoclonal Antibody (PTPN6/7543). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

PTPN6 Antibody in SDS-PAGE

PTPN6 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Tyrosine-protein phosphatase non-receptor type 6 Mouse Monoclonal Antibody (PTPN6/7543). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
PTPN6/7543
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
Gene Name
PTPN6
Positive Control
Human tonsil|lymph node or spleen.
Immunogen
Recombinant fragment (around aa395-595) of human PTPN6 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Key References
  • Zhang, Q., et al. Proc. Natl. Acad. Sci. U.S.A. (2005)
  • Kossev, P M, et al. The American Journal of Surgical Pathology, July 2001
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5777
SwissProt
P29350
Chromosome Location
12p13.31
Mol. Weight of Antigen
65kDa
Alternate Names
Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6; SHP1; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; 70 kda SHP-1L protein; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTPN6 / SHP

Summary

PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

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