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Progesterone Receptor (Marker of Progestin Dependence)

Recombinant Rabbit Monoclonal Antibody [Clone PGR/6854R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human breast carcinoma stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

SDS-PAGE Analysis Purified PR Recombinant Rabbit Monoclonal (PGR/6854R). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded horse smooth muscle stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

SDS-PAGE Analysis Purified PR Recombinant Rabbit Monoclonal (PGR/6854R). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded horse smooth muscle stained with PR Recombinant Rabbit Monoclonal Antibody (PGR/6854R).

Product Details

Synonyms

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Positive Control

Human breast carcinoma.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary)

Cellular Localization

Nucleus.

Species Reactivity

Human. Horse.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

PR-A (81kDa) and PR-B (116kDa).

Specificity & Comments

Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.