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Home >> Antibodies >> Progesterone Receptor (Marker of Progestin Dependence)

Progesterone Receptor (Marker of Progestin Dependence)

Mouse Monoclonal Antibody [Clone PGR/2694]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Progesterone Receptor Mouse Monoclonal Antibody (PGR/2694).

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SDS-PAGE Analysis Purified Progesterone Receptor Mouse Monoclonal Antibody (PGR/2694). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Progesterone Receptor Mouse Monoclonal Antibody (PGR/2694).

Product Details

Synonyms

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Positive Control

T47-D cells. Endometrial or Breast Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT) (our BEST clone)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human Progesterone Receptor (PGR) protein (around aa 483-571) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

PR-A (81kDa) and PR-B (116kDa).

Specificity & Comments

This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than estrogen receptor (ER) alone. This MAb is excellent for immunohistochemical staining of formalin-fixed tissues.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Press M, et al. Steroids. 2002 Aug; 67(9):799-813.
  2. Mote P, et al. J Clin Pathol., 2001; 54: 624-630.

Bioinformatics

  •  Entrez Gene ID: 5241
  •  Gene Symbol: PGR
  •  SwissProt: P06401
  •  Chromosome Location: 11q22.1
  •  Unigene: 2905
NBT02694