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Home >> Antibodies >> PAX2 (Renal Cell & Ovarian Carcinoma Marker)

PAX2 (Renal Cell & Ovarian Carcinoma Marker)

Mouse Monoclonal Antibody [Clone PAX2/1104]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with PAX2 Mouse Monoclonal Antibody (PAX2/1104).

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Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with PAX2 Mouse Monoclonal Antibody (PAX2/1104).

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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with PAX2 Mouse Monoclonal Antibody (PAX2/1104).

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SDS-PAGE Analysis Purified PAX2, Monoclonal Antibody (PAX2/1104). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using PAX2 Mouse Monoclonal Antibody (PAX2/1104).

Product Details

Synonyms

Paired box gene 2; paired box homeotic gene 2; paired box protein 2; Paired box protein Pax-2; Paired box protein Pax2

Positive Control

NAMALWA cells. Fetal kidney or Renal Cell Carcinoma (RCC) or Ovarian Carcinoma.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 223-354) human PAX2 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

42kDa

Specificity & Comments

Recognizes a protein of 42kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Tamimi, Y. Dietrich, K., Stone, K. and Grundy, P. 2006. Paired box genes, PAX2 and PAX8, are not frequently mutated in Wilms tumor. Mutat. Res.601: 46-50.

Bioinformatics

  •  Entrez Gene ID: 5076
  •  Gene Symbol: PAX2
  •  SwissProt: Q02962
  •  Chromosome Location: 10q24
  •  Unigene: 155644
NBT01104