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Recombinant PAX2 (Renal Cell & Ovarian Carcinoma Marker) Antibody [rPAX2/8506]

In Stock
Catalog Number Formulation Size Price
5076-MSM12-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5076-MSM12-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5076-MSM12-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 42kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

Product Properties & Targets

Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus
Gene Name
Positive Control
Human fetal kidney, renal cell carcinoma (RCC) or ovarian carcinoma.
Immunogen
Recombinant fragment (around aa 223-354) of human PAX2 protein (exact sequence is proprietary)
Alternate Names
Paired box protein Pax-2, Paired box 2; paired box protein 2; Paired box protein Pax-2; Paired box protein Pax2; PAX2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
rPAX2/8506
Chromosome Location
10q24
Mol. Weight of Antigen
42kDa

Functions

  • Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.

Key References

  • Tamimi, Y. Dietrich, K., Stone, K. and Grundy, P. 2006. Paired box genes, PAX2 and PAX8, are not frequently mutated in Wilms tumor. Mutat. Res.601: 46-50.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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