2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Nucleolar complex-associated protein 4-like protein (NOC4L)

Nucleolar complex-associated protein 4-like protein (NOC4L)

Mouse Monoclonal Antibody [Clone PCRP-NOC4L-1B2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

SDS-PAGE Analysis Purified NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2). Confirmation of Integrity and Purity of Antibody.

img

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

img

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (green); phalloidin (red).

Product Details

Synonyms

NOC4 protein homolog; NOC4-like protein; Nucleolar complex protein 4 homolog; Nucleolar complex-associated protein 4-like protein

Positive Control

HeLa or 293T cells.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NOC4L protein

Cellular Localization

Nucleus.

Species Reactivity

Human

Host / Ig Isotype

Mouse / IgG1

Mol. Weight of Antigen

58.4kDa

Specificity & Comments

Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Zhu et al., 2019, Cell Reports 27, 1205 1220.
  2. Blackshaw S., et al. Nature methods15.5 (2018 May): 330-338.
  3. Nucleic Acids Res. 38:D142-D148 (2010).

Bioinformatics

  •  Entrez Gene ID: 79050
  •  Gene Symbol: NOC4L
  •  SwissProt: Q9BVI4
  •  Chromosome Location: 12q24.33
  •  Unigene: 558536