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  • PCRP

Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody [PCRP-NOC4L-1B2]

Additional information

Catalog Number: 79050-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
79050-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
79050-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
79050-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody

SDS-PAGE Analysis of Purified NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2). Confirmation of Integrity and Purity of Antibody.

Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody - Image 2

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody - Image 3

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (green); phalloidin (red).

  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Clone
PCRP-NOC4L-1B2
Isotype
IgG1
Cellular Localization
Nucleolus, Nucleus, Nucleus membrane
Gene Name
NOC4L
Positive Control
HeLa or 293T cells.
Immunogen
Recombinant full-length human NOC4L protein
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Key References
  • Zhu et al., 2019, Cell Reports 27, 1205 1220.
  • Blackshaw S., et al. Nature methods15.5 (2018 May): 330-338.
  • Nucleic Acids Res. 38:D142-D148 (2010).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
79050
SwissProt
Q9BVI4
Chromosome Location
12q24.33
Mol. Weight of Antigen
58.4kDa
Alternate Names
Nucleolar complex protein 4 homolog, NOC4-like protein, Nucleolar complex-associated protein 4-like protein, NOC4 protein homolog; NOC4-like protein; Nucleolar complex protein 4 homolog; Nucleolar complex-associated protein 4-like protein

Summary

Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]

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