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Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody [PCRP-NOC4L-1B2]

In Stock
Catalog Number Formulation Size Price
79050-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
79050-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
79050-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2). Confirmation of Integrity and Purity of Antibody.

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (green); phalloidin (red).

Immunofluorescence Analysis of PFA-fixed HeLa cells. NOC4L Mouse Monoclonal Antibody (PCRP-NOC4L-1B2) followed by goat anti-mouse IgG-CF488 (green); phalloidin (red).

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleolus, Nucleus, Nucleus membrane
Gene Name
NOC4L
Positive Control
HeLa or 293T cells.
Immunogen
Recombinant full-length human NOC4L protein
Alternate Names
Nucleolar complex protein 4 homolog, NOC4-like protein, Nucleolar complex-associated protein 4-like protein, NOC4 protein homolog; NOC4-like protein; Nucleolar complex protein 4 homolog; Nucleolar complex-associated protein 4-like protein

Database Links

Entrez Gene ID
79050
SwissProt
Q9BVI4

Additional Information

Clone
PCRP-NOC4L-1B2
Chromosome Location
12q24.33
Mol. Weight of Antigen
58.4kDa

Related Antibodies

View All NOC4L Antibodies

Key References

  • Zhu et al., 2019, Cell Reports 27, 1205 1220.
  • Blackshaw S., et al. Nature methods15.5 (2018 May): 330-338.
  • Nucleic Acids Res. 38:D142-D148 (2010).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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