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Home >> Antibodies >> NOX4 / NADPH Oxidase 4

NOX4 / NADPH Oxidase 4

Mouse Monoclonal Antibody [Clone NOX4/1245]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified NOX4 Mouse Monoclonal Antibody (NOX4/1245). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; NADPH oxidase 4; Nox4; Renal NAD(P)H-oxidase; RENOX

Positive Control

PC-12, JAR cells. Kidney.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human NOX4 protein

Cellular Localization

Cytoplasm and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

70kDa

Specificity & Comments

The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Geiszt, M., et al. 2000. Proc. Natl. Acad. Sci. USA 97: 8010-8014.
  2. Shiose, A., et al. 2001. J. Biol. Chem. 276: 1417-1423.

Bioinformatics

  •  Entrez Gene ID: 50507
  •  Gene Symbol: NOX4
  •  SwissProt: Q9NPH5
  •  Chromosome Location: 11q14.2-q21
  •  Unigene: 371036
NBT01245