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Home >> Antibodies >> NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)

NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)

Mouse Monoclonal Antibody [Clone NKX3.1/3348]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified AbWITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified AbWITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with NKX3.1-Monospecific Mouse Monoclonal Antibody (NKX3.1/3348).

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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with NKX3.1-Monospecific Mouse Monoclonal Antibody (NKX3.1/3348).

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SDS-PAGE Analysis Purified NKX3.1-Monospecific Mouse Monoclonal Antibody (NKX3.1/3348). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using NKX3.1-Monospecific Mouse Monoclonal Antibody (NKX3.1/3348).

Product Details

Synonyms

NK3 Transcription Factor Related, Locus 1; NK Homeobox (Drosophila), Family 3, A; NK3 Transcription Factor Homolog A; NK Homeobox, Family 3, A; Homeobox Protein Nkx-3.1; BAPX2; NKX3

Positive Control

Highly expressed in the prostate and at a lower level in the testis.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinantfragment(around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

35kDa

Specificity & Comments

NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA &azide at 1.0mg/ml.

Key References

  1. Zhang P., et al. Mol Biol Rep. 2010 Mar;37(3):1505-12.
  2. Gurel B., et al. Am J Surg Pathol. 2010 Aug;34(8):1097-105.

Bioinformatics

  •  Entrez Gene ID: 4824
  •  Gene Symbol: NKX3-1
  •  SwissProt: Q99801
  •  Chromosome Location: 8p21.2
  •  Unigene: 55999
NBT03348