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Home >> Antibodies >> NK1.1 / CD161c / Klrb1c, Mouse

NK1.1 / CD161c / Klrb1c, Mouse

Mouse Monoclonal Antibody [Clone PK136]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified NK1.1 Mouse Monoclonal Antibody (PK136). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CD161 antigen-like family member C; CD161c; Killer cell lectin-like receptor subfamily B member 1C (Klrb1c); Klrb1f; Lymphocyte antigen 55c (Ly55c); Lymphocyte antigen 59; Natural killer cell surface protein P1-40; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; NKRP1

Positive Control

MPBMC's or Thymus or Lymph Node.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF         More Details

Functional Studies (Order Antibody without BSA & Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

CD Mouse spleen and bone marrow cells enriched for NK-1+ cells

Cellular Localization

Cell Surface

Species Reactivity

Mouse. Does not react with Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

kDa

Specificity & Comments

NK1.1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene.It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes.NK1.1 is expressed in some Mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cellsin vitroand rejection of bone marrow allograftsin vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1.1 is commonly used as a Mouse NK cell marker.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  2. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  3. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  4. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  5. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)

Bioinformatics

  •  Entrez Gene ID: 17059
  •  Gene Symbol: Klrb1c (Mouse)
  •  SwissProt: P27814
  •  Chromosome Location: 6 F3; 6 63.09 cM (Mouse)
  •  Unigene: 480764
NBT02010