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NK1.1 / CD161c / Klrb1c, Mouse Antibody [PK136]

Additional information

Catalog Number: MSM1-2010
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
MSM1-2010-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
MSM1-2010-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
MSM1-2010-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
NK1.1 / CD161c / Klrb1c, Mouse Antibody

SDS-PAGE Analysis of Purified NK1.1 Mouse Monoclonal Antibody (PK136). Confirmation of Integrity and Purity of Antibody.

  • Flow
  • Functional Studies
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Mouse
Clone
PK136
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Membrane
Gene Name
Klrb1c
Positive Control
MPBMC's or Thymus or Lymph Node.
Immunogen
CD Mouse spleen and bone marrow cells enriched for NK-1+ cells
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
Key References
  • Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  • Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  • Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  • Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  • Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC)
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
17059
SwissProt
P27814
Chromosome Location
6 F3; 6 63.09 cM (Mouse)
Mol. Weight of Antigen
kDa
Alternate Names
Killer cell lectin-like receptor subfamily B member 1C, CD161 antigen-like family member C, Lymphocyte antigen 55c, NK1.1, NKR-P1.9, NKR-P1C, Natural killer cell surface protein P1-40, CD161 antigen-like family member C; CD161c; Killer cell lectin-like receptor subfamily B member 1C (Klrb1c); Klrb1f; Lymphocyte antigen 55c (Ly55c); Lymphocyte antigen 59; Natural killer cell surface protein P1-40; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; NKRP1

Summary

NK1.1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene.It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes.NK1.1 is expressed in some Mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cellsin vitroand rejection of bone marrow allograftsin vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1.1 is commonly used as a Mouse NK cell marker.

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