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Home >> Antibodies >> Napsin A (Lung Adenocarcinoma Marker)

Napsin A (Lung Adenocarcinoma Marker)

Biotinylated Mouse Monoclonal Antibody [Clone NAPSA/3308]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

499.00

Formulation

Purified Ab conjugated to Biotin

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to Biotin

Price (USD)

499.00
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Formalin-fixed, paraffin-embedded human lung adenocarcinoma stained with Biotin-conjugated Napsin A Mouse Monoclonal Antibody (NAPSA/3308).

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Formalin-fixed, paraffin-embedded human lung adenocarcinoma stained with Biotin-conjugated Napsin A Mouse Monoclonal Antibody (NAPSA/3308).

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SDS-PAGE Analysis Purified Naspin A Mouse Monoclonal Antibody (NAPSA/3308) (unconjugated). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Napsin A Mouse Monoclonal Antibody (NAPSA/3308).

Product Details

Synonyms

ASP4, Aspartyl protease 4, KAP, Kidney derived aspartic protease like protein (Kdap), NAP1, NAPA, Napsa, napsin A aspartic peptidase, Pronapsin A, SNAPA

Positive Control

Lung adenocarcinoma

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °
C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Napsin A protein fragment (aa189-299) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

37kDa

Specificity & Comments

Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B.There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.

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Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Key References

  1. Bishop, JA et. al. Hum Pathol 41: 20-25
  2. Ordonez, NG 2012 Adv Anat Pathol 19: 66-73
  3. Ye, J et. al.Appl Immunhistochem Mol Morphol 19: 313-317

Bioinformatics

  •  Entrez Gene ID: 9476
  •  Gene Symbol: NAPSA
  •  SwissProt: O96009
  •  Chromosome Location: 19q13.33
  •  Unigene: 512843