Recombinant Napsin A (Lung Adenocarcinoma Marker) [NAPSA/7165R]

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Summary

Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B. �There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.

Product Properties & Targets

Host
Rabbit
Species Reactivity
Human
Isotype
IgG, kappa
Cellular Localization
Cytoplasm.
Gene Name
NAPSA
Positive Control
Human lung adenocarcinoma.
Immunogen
Recombinant fragment (aa50-150) of human Napsin A protein (exact sequence is proprietary)
Alternate Names
Napsin-A, Aspartyl protease 4, Napsin-1, TA01/TA02, ASP4, Aspartyl protease 4, KAP, Kidney derived aspartic protease like protein (Kdap), NAP1, NAPA, Napsa, napsin A aspartic peptidase, Pronapsin A, SNAPA

Database Links

Entrez Gene ID
9476
Unigene
512843
SwissProt
O96009

Additional Information

Clone
NAPSA/7165R
Human Gene Symbol
NAPSA
Chromosome Location
19q13.33
Mol. Weight of Antigen
37kDa

Functions

  • May be involved in processing of pneumocyte surfactant precursors.

Known Applications & Suggested Dilutions

  • Western Blot (1-2ug/ml)
  • ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Bishop, JA et. al. Hum Pathol 41: 20-25
  • Ordonez, NG 2012 Adv Anat Pathol 19: 66-73
  • Ye, J et. al.Appl Immunhistochem Mol Morphol 19: 313-317

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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