Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MSH6 Mouse Monoclonal Antibody (MSH6/2927).
Formalin-fixed, paraffin-embedded human Lymph Node stained with MSH6 Mouse Monoclonal Antibody (MSH6/2927).
SDS-PAGE Analysis Purified MSH6 Mouse Monoclonal Antibody (MSH6/2927). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing >19,000 full-length human proteins using MSH6 Mouse Monoclonal Antibody (MSH6/2927)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.