Formalin-fixed, paraffin-embedded human Lung Mesothelioma stained with Mesothelin Mouse Monoclonal Antibody (SPM143).
Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Mesothelin Mouse Monoclonal Antibody (SPM143).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.