2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603
Catalog #
Size
Price (USD)
Formulation
Catalog No
Size
Formulation
Price (USD)
Formalin-fixed, paraffin-embedded human Pancreas stained with MAML3 Monoclonal Antibody (MAML3/1303).
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).
Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).
Formalin-fixed, paraffin-embedded human Placenta stained with MAML3 Monoclonal Antibody (MAML3/1303).
SDS-PAGE Analysis Purified MAML3 Monoclonal Antibody (MAML3/1303). Confirmation of Purity and Integrity of Antibody.
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
Key References
