Formalin-fixed, paraffin-embedded human Pancreas stained with MAML2 Monoclonal Antibody (MAML2/1302).
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
Formalin-fixed, paraffin-embedded human Placenta stained with MAML2 Monoclonal Antibody (MAML2/1302).
SDS-PAGE Analysis Purified MAML2 Monoclonal Antibody (MAML2/1302). Confirmation of Purity and Integrity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.