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Home >> Antibodies >> LH-beta(Luteinizing Hormone-beta)

LH-beta(Luteinizing Hormone-beta)

Recombinant Mouse Monoclonal Antibody [Clone rLHb/1613]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human pituitary stained with LH-beta Recombinant Mouse Monoclonal Antibody (rLHb/1613). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

SDS-PAGE Analysis Purified LH-beta Recombinant Mouse Monoclonal Antibody (rLHb/1613). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ChorionicGonadotropin, Betapolypeptide 4 (CGB4); hLHB; Interstitial cell stimulating hormone beta chain; Leutropin; LH-B; LHB; LSH-B; LSH-beta; Luteinizing hormone beta polypeptide; Lutropin beta chain

Positive Control

Anterior Pituitary

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human LHB protein

Cellular Localization

Cytoplasm.Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

22kDa

Specificity & Comments

LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Couzinet, B., et al. 1993. The control of gonadotrophin secretion by ovarian steroids. Hum. Reprod. 2: 97-101.

Bioinformatics

  •  Entrez Gene ID: 3972
  •  Gene Symbol: LHB
  •  SwissProt: P01229
  •  Chromosome Location: 19q13.32
  •  Unigene: 154704