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Home >> Antibodies >> Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker)

Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker)

Mouse Monoclonal Antibody [Clone NRG1/2710]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710).

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SDS-PAGE Analysis Purified Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Heregulin-1 Mouse Monoclonal Antibody (NRG1/2710).

Product Details

Synonyms

Acetylcholine receptor-inducing activity (ARIA); Breast cancer cell differentiation factor p45; Glial growth factor (GGF2); Heregulin-1; Heregulin, alpha (45kD, ERBB2 p185-activator); HGL; HRG1; HRGA; MST131; Neu Differentiation Factor (NDF); Neuregulin-1; NRG1; Sensory and Motor Neuron-Derived Factor (SMDF)

Positive Control

A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic (Secreted)

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

26-71kDa

Specificity & Comments

Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Meyer, D., et al. 1997. Isoform-specific expression and function of neuregulin. Development 124: 3575-3586.

Bioinformatics

  •  Entrez Gene ID: 3084
  •  Gene Symbol: NRG1
  •  SwissProt: Q02297
  •  Chromosome Location: 8p12
  •  Unigene: 453951, 668810
NBT02710