Formalin-fixed, paraffin-embedded human spleen stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
Formalin-fixed, paraffin-embedded human tonsil stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
SDS-PAGE Analysis Purified GZMB Recombinant Rabbit Monoclonal Antibody (GZMB/6530R). Confirmation of Integrity and Purity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.