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Gamma-parvin

Mouse Monoclonal Antibody [Clone 8C5.2]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human tonsil stained with Gamma parvin Mouse Monoclonal Antibody (8C5.2) at 2ug/ml in PBS. Inset: PBS instead of primary, secondary only antibody control.

SDS-PAGE Analysis Purified Gamma parvin Mouse Monoclonal Antibody (8C5.2). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human tonsil stained with Gamma parvin Mouse Monoclonal Antibody (8C5.2) at 2ug/ml in PBS. Inset: PBS instead of primary, secondary only antibody control.

SDS-PAGE Analysis Purified Gamma parvin Mouse Monoclonal Antibody (8C5.2). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Gamma parvin; PARVG

Positive Control

Jurkat cells. Human tonsil or stomach.

Known Applications & Suggested Dilutions

IP, Western Blot, IHC-P More Details

Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate))
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

GST-tagged recombinant protein corresponding to human Gamma-parvin

Cellular Localization

Cytoplasm. Cell Surface.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

37kDa

Specificity & Comments

The parvin family, including -parvin, -parvin and -parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, -actinin and testicular kinase 1. -parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of -parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. -parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK--parvin complex is essential for the establishment of cell polarity required for leukocyte migration.