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Filaggrin(Keratinocyte Differentiation Marker)

Biotinylated Mouse Monoclonal Antibody [Clone FLG/1563]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to Biotin

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to Biotin

Price (USD)


Formalin-fixed, paraffin-embedded human skin stained with Biotin-conjugated FilaggrinMouse Monoclonal Antibody(FLG/1563).


SDS-PAGE Analysis Purified FilaggrinMouse Monoclonal Antibody(FLG/1563) (unconjugated). Confirmation of Integrity and Purity of Antibody.


Analysis of Protein Array containing more than 19,000 full-length human proteins using Filaggrin Mouse Monoclonal Antibody (FLG/1563).

Product Details


ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin

Positive Control

U-251-MGcells.Human skin.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °
C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.


Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary)

Cellular Localization


Species Reactivity


Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

26-45kDa (Processed); 350kDa (Profilaggrin)

Specificity & Comments

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Related Products

Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Key References

  1. Gan, S.Q., et al. 1990. Biochemistry 29: 9432-9440.


  •  Entrez Gene ID: 2312
  •  Gene Symbol: FLG
  •  SwissProt: P20930
  •  Chromosome Location: 1q21.3
  •  Unigene: 654510