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Home >> Antibodies >> Cdk2 / p34cdc2 Serine-Threonine Kinase

Cdk2 / p34cdc2 Serine-Threonine Kinase

Mouse Monoclonal Antibody [Clone AN4.3]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified Cdk1 Mouse Monoclonal Antibody (AN4.3). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

Cdc2 related protein kinase; CDC28; CDC2A; CDK1; CDK2; CDKN2; Cell devision kinase 2; Cell division protein kinase 2; cyclin dependent kinase 2 alpha; kinase Cdc2; MPF; p33 protein kinase

Positive Control

HeLa cells. HeLa whole cell lysate.

Known Applications & Suggested Dilutions

IP, Kinase Assay, Western Blot, Flow cytometry         More Details

Inhibits activation of p34cdc2 kinase by cyclins
Immunoprecipitation
Kinase Assay
Western Blot
Flow cytometry (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Cdk2 protein

Cellular Localization

Nuclear

Species Reactivity

Human. Mouse. Xenopus.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

34kDa

Specificity & Comments

In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclindependent kinase 2 (Cdk2), also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2-related cyclin dependent kinases have been identified. These include Cdk3, Cdk4, Cdk5, PCTAIRE-1, PCTAIRE-2, PCTAIRE-3, Cdk6 Cdk7, Cdk8 and KKIALRE.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Syafrizayanti et al. 2017. Sci Rep. 7:39756.

Bioinformatics

  •  Entrez Gene ID: 1017
  •  Gene Symbol: CDK2
  •  SwissProt: P24941
  •  Chromosome Location: 12q13.2
  •  Unigene: 19192
NBT02316