Home >> Antibodies >> CD64

CD64

Mouse Monoclonal Antibody [Clone FCGR1A/4950]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Product Details

Synonyms

CD64; CD64A; CD64b; CD64c; Fc fragment of IgG, high affinity Ia, receptor (CD64); FCGR1; FCGR1A; FCGR1B; FCGR1C; FcRI; FcRIB; FCRIC; High affinity immunoglobulin gamma Fc receptor IB; IGFR1; IGFRB; IGFRC

Positive Control

Human tonsil.

Known Applications & Suggested Dilutions

WB, Immunohistology More Details

Western Blotting (1-2ug/ml)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

FCG10.1A / CD64 antibody was raised against rheumatoid synovial fluid cells and fibronectin purified human monocytes.

Cellular Localization

Cell Membrane

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

Three different classes of IgG Fc receptors have been described: Fc RI (CD64), Fc RII (CD32) and Fc RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN- stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.