Formalin-fixed, paraffin-embedded human Colon Ganglion stained with CD56 Monoclonal Antibody (123C3.D5)
SDS-PAGE Analysis Purified CD56 Monoclonal Antibody (123C3.D5). Confirmation of Integrity and Purity of Antibody
Flow cytometry of lymphocyte gated PBMCs unstained (gray) orstained with CF568-labeled CD56 monoclonal antibody (123C3.D5) (orange).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.