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Home >> Antibodies >> CD1c

CD1c

Mouse Monoclonal Antibody [Clone CD1C/1603]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD1c Mouse Monoclonal Antibody (CD1C/1603). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

BDCA1; CD1; CD1A; CD1c; CD1C antigen c polypeptide; CD1c molecule; Cortical thymocyte antigen CD1C; Differentiation antigen CD1 alpha 3; R7; T cell surface glycoprotein CD1c

Positive Control

Expressed on cortical thymocytes, on certain T-cell leukemias and in various other tissues.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CD1c protein

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

43kDa

Specificity & Comments

The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Martin, L.H., et al. 1987. Proc. Natl. Acad. Sci. USA 84: 9189-9193.

Bioinformatics

  •  Entrez Gene ID: 911
  •  Gene Symbol: CD1C
  •  SwissProt: P29017
  •  Chromosome Location: 1q23.1
  •  Unigene: 132448
NBT01603