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Home >> Antibodies >> CD171 / NCAM-L1 (L1 Cell Adhesion Molecule)

CD171 / NCAM-L1 (L1 Cell Adhesion Molecule)

Mouse Monoclonal Antibody [Clone SPM275]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified CD171 Mouse Monoclonal Antibody (SPM275). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CAML1, HSAS1, Hyd, L1 Cell Adhesion Molecule, L1-NCAM, MASA, MIC5, NCAM-L1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, S10, SPG1

Positive Control

Neuroblastomas or Schwannomas.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-Fr         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Frozen) (1-2ug/ml for 30 min at RTOptimal dilution for a specific application should be determined.

Immunogen

Homogenous suspension of 16-week human fetal brain

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

220-240kDa

Specificity & Comments

Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kemshead J, et. al. International J Cancer, 1983; 31:187-195.
  2. Patel, et. al. Biochem Soc Transactions, 1990; 18:274.

Bioinformatics

  •  Entrez Gene ID: 3897
  •  Gene Symbol: L1CAM
  •  SwissProt: P32004
  •  Chromosome Location: Xq28
  •  Unigene: 52818
NBT00679