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Home >> Antibodies >> CD127 / IL7R (Marker of T-Reg Cells)

CD127 / IL7R (Marker of T-Reg Cells)

Mouse Monoclonal Antibody [Clone IL7R/2751]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Western Blot Analysis of Human K562, Jurkat, HeLa and Ramos cell lysate using CD127 Mouse Monoclonal Antibody (IL7R/2751).

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SDS-PAGE Analysis Purified CD127 Mouse Monoclonal Antibody (IL7R/2751). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using CD127 Mouse Monoclonal Antibody (IL7R/2751)

Product Details

Synonyms

CD127; IL-7 receptor subunit alpha; IL-7R-alpha; IL7R; IL7RA; IL7R alpha; ILRA; Interleukin 7 receptor alpha chain; Interleukin 7 receptor

Positive Control

K562, HeLa, Daudi or Jurkat cells. Tonsil, Lymph Node or Spleen.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order Ab without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 21-236) of human CD127 protein (IL7R) (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

52-72kDa

Specificity & Comments

The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Weihong Liu et. al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006 Jul 10; 203(7): 1701-1711.

Bioinformatics

  •  Entrez Gene ID: 3575
  •  Gene Symbol: IL7R
  •  SwissProt: P16871
  •  Chromosome Location: 5p13.2
  •  Unigene: 591742, 635723
NBT02751