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CD127 / IL7R (Marker of T-Reg Cells) Antibody [IL7R/2751]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
3575-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3575-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3575-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Western Blot (WB)
2-4ug/ml

Summary

The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID).

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2c / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
Positive Control
Daudi or Jurkat cells. Tonsil, HeLa, K562, lymph node or spleen.
Immunogen
Recombinant fragment (around aa 21-236) of human CD127 protein (IL7R) (exact sequence is proprietary)
Alternate Names
Interleukin-7 receptor subunit alpha, CDw127, CD127; IL-7 receptor subunit alpha; IL-7R-alpha; IL7R; IL7RA; IL7R alpha; ILRA; Interleukin 7 receptor alpha chain; Interleukin 7 receptor

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IL7R/2751
Chromosome Location
5p13.2
Mol. Weight of Antigen
52-72kDa

Functions

  • Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Key References

  • Weihong Liu et. al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006 Jul 10; 203(7): 1701-1711.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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