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Home >> Antibodies >> Calcineurin A / PPP3CA

Calcineurin A / PPP3CA

Mouse Monoclonal Antibody [Clone BF1.1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

Calcineurin A alpha; Calcineurin A1; Calcineurin A; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA alpha; CNA1; Ppp3ca; Protein phosphatase 2B catalytic subunit (PPP2B); Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform (PPP3CA)

Positive Control

HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order antibody without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length Calcineurin A protein

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

62kDa

Specificity & Comments

Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Stemmer, P.M and C.B. Klee (1994) Biochemistry 33:6859.
  2. Zeng H. et al. (2001) Cell 107:617.

Bioinformatics

  •  Entrez Gene ID: 5530
  •  Gene Symbol: PPP3CA
  •  SwissProt: Q08209
  •  Chromosome Location: 4q24
  •  Unigene: 435512
NBT02283