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SDS-PAGE Analysis Purified Beta-2-Microglobulin Mouse Monoclonal Antibody (C21.48A1). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of THP-1 and Raji cell lysate using Beta-2-Microglobulin Mouse Monoclonal Antibody (C21.48A1).
Flow Cytometric Analysis of PFA-fixed HeLa cells using Beta-2-Microglobulin Mouse Monoclonal Antibody (C21.48A1) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red)
Immunofluorescent staining of HeLa cells. Beta-2-Microglobulin Mouse Monoclonal Antibody (C21.48A1); followed by goat anti-mouse IgG-CF488 (Green).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. Beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Key References
