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Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody [SPM617]

Additional information

Catalog Number: 567-MSM2X
Reactivity:

,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
567-MSM2X-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
567-MSM2X-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
567-MSM2X-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody

Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Beta-2-Microglobulin Monoclonal Antibody (SPM617)

Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Image 2

Immunofluorescent staining of HeLa cells. Beta-2-Microglobulin MAb (SPM617); followed by goat anti-mouse IgG-CF488 (Green).

Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Image 3

Flow Cytometric Analysis of PFA fixed HeLa cells using Beta-2-Microglobulin MAb (SPM617) followed by Goat anti-mouse IgG-CF488 (Blue); Goat anti-mouse IgG-CF488 Is Control (Red).

Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Image 4

Western Blot Analysis of THP-1 and Raji Cell lysate using Beta-2-Microglobulin MAb (SPM617).

  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human, Non-Human primates
Clone
SPM617
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell surface, Secreted
Gene Name
B2M
Positive Control
Cervix, Endometrial, HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Kidney or Colon.
Immunogen
Full length recombinant human B2M protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Key References
  • Liabeuf A, le Borgne de Kaouel C, Kourilsky FM, Malissen B, Manuel Y, Sanderson AR. An antigenic determinant of human beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies. J Immunol. 1981 Oct;127(4):1542-8.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
567
SwissProt
P61769
Chromosome Location
15q21-q22.2
Mol. Weight of Antigen
12kDa
Alternate Names
Beta-2-microglobulin, B2M; Beta 2 microglobin; Beta 2 microglobulin; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; Hdcma22p

Summary

Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin’s lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

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