Formalin-fixed, paraffin-embedded human Spleen stained with Bcl-2 Rabbit Recombinant Monoclonal Antibody (BCL2/1878R).
SDS-PAGE Analysis Purified Bcl-2 Rabbit Recombinant Monoclonal Antibody (BCL2/1878R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human MCF-7 cell lysate using Bcl-2 Rabbit Recombinant Monoclonal Antibody (BCL2/1878R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.