SDS-PAGE Analysis Purified AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence Analysis of A549 cells labeling AKR1B1. AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2) followed by goat anti-mouse IgG-CF488. Nuclei stained with RedDot (blue).
Western Blot Analysis of HeLa cell lysate using AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2).
Formalin-fixed, paraffin-embedded human prostate stained with AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2).
Analysis of Protein Array containing more than 19,000 full-length human proteins using AKR1B1Mouse Monoclonal Antibody (CPTC-AKR1B1-2).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
AKR1B1, also deisgnated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.