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Home >> Antibodies >> Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)

Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)

Mouse Monoclonal Antibody [Clone CPTC-AKR1B1-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2). Confirmation of Purity and Integrity of Antibody.

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Immunofluorescence Analysis of A549 cells labeling AKR1B1 with AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Blue)

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Aldo-keto Reductase Family 1 Member B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2).

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Western Blot Analysis of HeLa cell lysate usingAKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2).

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Formalin-fixed, paraffin-embedded human prostate stained with AKR1B1 Mouse Monoclonal Antibody (CPTC-AKR1B1-2).

Product Details

Synonyms

Aldehyde Reductase 1; Aldo-keto reductase family 1 member B1 (AKR1B1); Aldose reductase (AR); Lii5-2 CTCL tumor antigen; low Km aldose reductase

Positive Control

549, 293T, A431, HeLa, HepG2, MOLT4 and Raji whole cell lysates; HeLa cells; Human colon carcinoma tissue.

Known Applications & Suggested Dilutions

Western Blot, IF, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human AKR1B1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

37kDa

Specificity & Comments

AKR1B1, also deisgnated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bohren, K.M., et al. J. Biol. Chem. 264: 9547-9551.
  2. Lefrancois-Martinez, Anne-Marie, et al. OUP Academic, Oxford University Press, 1 June 2004.

Bioinformatics

  •  Entrez Gene ID: 231
  •  Gene Symbol: AKR1B1
  •  SwissProt: P15121
  •  Chromosome Location: 7q33
  •  Unigene: 521212
NBT02592