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Home >> Antibodies >> 26S proteasome non-ATPase regulatory subunit 4

26S proteasome non-ATPase regulatory subunit 4

Mouse Monoclonal Antibody [Clone CPTC-PSMD4-3]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified PSMD4Mouse Monoclonal Antibody (CPTC-PSMD4-3). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of Liver tissue lysate using PSMD4Mouse Monoclonal Antibody (CPTC-PSMD4-3).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using 26S proteasome non-ATPase regulatory subunit 4 Mouse Monoclonal Antibody (CPTC-PSMD4-3).

Product Details

Synonyms

26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, AF, AF-1

Positive Control

Jurkat or HepG2 cells. Liver tissue lysate. Human liver, tonsil or kidney.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human PSMD4protein

Cellular Localization

Nucleus and cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

50kDa

Specificity & Comments

In eukaryotic cells, selective breakdown of cellular proteins is ensured by two distinct pathways. First, appropriate proteins are tagged for degradation by ubiquitination. Second, these multiubiquitinated proteins are degraded by the highly selective 26S Proteasome protein-destroying machinery. At specific stages of development, embryo- and tissue-specific components of the 26S Proteasome are formed, which are termed Rpn10a through Rpn10e, or alternatively pUb-R2 through pUb-R5. All members of this family can be generated by a single Rpn10 gene by developmentally regulated alternative splicing. The pUb-R2 subunit, originally identified as S5a (also designated antisecretory factor and multiubiquitin chain binding protein) is ubiquitously expressed and may perform proteolysis constitutively in a wide variety of cells. pUb-R4 and pUb-R5 may have embryo- or tissue-specific expression and may play specialized roles in early embryonic development.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lonnroth, I, et al. 1986. Biochim.Biophys. Acta 883: 138-144.

Bioinformatics

  •  Entrez Gene ID: 5710
  •  Gene Symbol: PSMD4
  •  SwissProt: P55036
  •  Chromosome Location: 1q21.3
  •  Unigene: 505059
NBT02261