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SMNDC1 Antibody [PCRP-SMNDC1-1A9]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
10285-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10285-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10285-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2b /
Cellular Localization
Cajal body, Nucleus, Nucleus speckle
Gene Name
Positive Control
HeLa or HepG2 cells.
Immunogen
Recombinant full-length human SMNDC1 protein
Alternate Names
Survival of motor neuron-related-splicing factor 30, 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1, 30 kDa splicing factor SMNrp; MGC106917; MGC112663; SMN related protein; SMNR; SPF30; Splicing factor 30, survival of motor neuron-related; Survival motor neuron domain containing protein 1; Survival of motor neuron related splicing factor 30

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-SMNDC1-1A9
Chromosome Location
10q25.2
Mol. Weight of Antigen
30kDa

Functions

  • Involved in spliceosome assembly.

Key References

  • Talbot, K., et al. 1998. Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex. Hum. Mol. Genet. 7: 2149-2156.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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