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KLF17/ ZNF393 Antibody [PCRP-KLF17-1G2]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
128209-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
128209-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
128209-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml

Summary

Kr ppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and which co-regulators they interact with. KLF17 (Kr ppel-like factor 17), whose alternative names include ZNF393 (zinc finger protein 393) or zfp393, is a 389 amino acid nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family. Expressed in testis and ovary, KLF17 may function as a germ cell-specific transcription factor involved in oocyte development and spermatid differentiation. Containing three C2H2-type zinc fingers which bind G/C-rich sites, KLF17 activates transcription from CACCC-box elements.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa cells.
Immunogen
Recombinant full-length human KLF17protein
Alternate Names
Krueppel-like factor 17, Zinc finger protein 393, Kruppel Like Factor 17; Zinc Finger Protein 393; ZNF393; Novel Zinc-Finger Protein; FLJ40160; ZLF393; KLF17

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-KLF17-1G2
Chromosome Location
1p34.1
Mol. Weight of Antigen
43kDa (predicted); 57kDa (observed)

Functions

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Key References

  • van Vliet, Jane et al. Genomics vol. 87,4 (2006): 474-82. doi:10.1016/j.ygeno.2005.12.011

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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