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KLF12 Antibody [PCRP-KLF12-1E3]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
11278-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
11278-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
11278-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or 293T cells.Human lymph node, spleen or colon.
Immunogen
Recombinant full-length human KLF12 protein
Alternate Names
Krueppel-like factor 12, Transcriptional repressor AP-2rep, AP-2rep, AP2REP, HSPC122

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-KLF12-1E3
Chromosome Location
13q22.1
Mol. Weight of Antigen
44.24kDa

Functions

  • Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Key References

  • Sutcliffe EG, et al. Cancer Genet, 2020 Aug. PMID 32805687

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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