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Fos-related antigen 2 (FRA-2) / FOS-like antigen 2 (FOSL2) Antibody [PCRP-FOSL2-1B1]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
2355-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2355-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2355-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

The Fos related gene, Fra-2, was initially molecularly cloned from chicken genomic DNA and shown to represent a new member of the immediate early gene family. The human counterpart of the chicken Fra-2 gene has since been described. Sequence alignment shows that the amino acid sequences conserved among Fra-2, c-Fos, Fra-1 and Fos B are contained in five regions. Region 2, the longest and most highly conserved region, contains the leucine zipper structure and the basic region, suggesting that like Fos, Fra-1 and Fos B, Fra-2 also forms heterodimers with c-Jun that recognize a specific DNA sequence such as the binding site for transcription factor AP-1. Such a model is further supported by the finding that the Fra-2 gene product forms a complex with c-Jun in growth-stimulated cells

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa, MCF7 or 293T cells.
Immunogen
Recombinant full-length human FOSL2 protein
Alternate Names
Fos-related antigen 2, FLJ23306; FOS like antigen 2; Fos-related antigen 2 (FRA-2); Fosl2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-FOSL2-1B1
Chromosome Location
2p23.2
Mol. Weight of Antigen
40kDa

Functions

  • Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).

Key References

  • Blackshaw S., et al. Nature methods 15.5 (2018 May): 330-338.
  • Sambucetti, L.C., et al. 1986. Science 234: 1417-1419.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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