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Formalin-fixed, paraffin-embedded human colon carcinoma stained with E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525).
Western Blot Analysis of MCF-7 cell lysate using E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525).
SDS-PAGE Analysis Purified E-Cadherin Mouse Recombinant Monoclonal (rCDH1/1525). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence Analysis of MCF-7 cells labeling CHD1 with E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525) followed by goat anti-mouse IgG-CF488 (green). Nuclear counterstain is RedDot.
Analysis of Protein Array containing >19,000 full-length human proteins using E-Cadherin Recombinant Mouse Monoclonal Antibody (rCDH1/1525) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Western Blot Analysis of human placenta tissue lysate using CDH1 Recombinant Mouse Monoclonal Antibody (rCDH1/1525).
Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as å°¾-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
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