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CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody

Additional information

Catalog Number: 909-RBP7
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
909-RBP7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
909-RBP7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
909-RBP7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody

Formalin-fixed, paraffin-embedded human Skin stained with CD1a Rabbit Polyclonal Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Rabbit Polyclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Endosome membrane, Membrane raft
Gene Name
CD1A
Positive Control
MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
Immunogen
Recombinant human CD1a protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Key References
  • McNally, AK. et al. 2011. Exp. Mol. Pathol. 91: 673-681.
  • Gulubova, M. et al. 2008. Clin. Exp. Metastasis. 25: 777-785.
  • Matsuda, A. et al. 2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877.
  • Cassaday, RD. et al. 2007. Clin. Cancer Res. 13: 540-549.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
909
SwissProt
P06126
Chromosome Location
1q23.1
Mol. Weight of Antigen
49kDa
Alternate Names
T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a antibody, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A

Summary

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

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