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Flow cytometric analysis of PFA-fixed HeLa cells. CBFB Mouse Monoclonal Antibody (PCRP-CBFB-1E6) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
SDS-PAGE Analysis of Purified CBFB Mouse Monoclonal Antibody (PCRP-CBFB-1E6). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence Analysis of PFA-fixed U87 cells stained using CBFB Mouse Monoclonal Antibody (PCRP-CBFB-1E6) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
Western blot analysis of HeLa cell lysate using CBFB Mouse Monoclonal Antibody (PCRP-CBFB-1E6).
Analysis of Protein Array containing more than 19,000 full-length human proteins using CBFB-Monospecific Mouse Monoclonal Antibody (PCRP-CBFB-1E6). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
The transcription factor polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (osteoblast-specific transcription factor), CBFA1 (core binding factor) and AML3 (acute myeloid leukemia), is composed of two subunits, 伪 and 尾, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2伪 subunits, PEBP2伪A, PEBP2伪B and PEBP2伪C, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory 尾 subunit, which facilitates DNA binding of the 伪 subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2尾 is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle Myosin heavy chain, producing a chimeric gene, PEBP2尾/CBFB-SMMHC, that is associated with human acute myeloid leukemia.
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