Formalin-fixed, paraffin-embedded human Small Intestine stained with Villin Mouse Monoclonal Antibody (VIL1/1314 + VIL1/2376).
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Villin Mouse Monoclonal Antibody (VIL1/1314 + VIL1/2376).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 95kDa, which is identified as villin. It is a major constituent in the microvilli, which compose the brush border of epithelial cells forming absorptive surfaces of the intestinal and renal proximal tubular epithelia. Anti-Villin labels the brush border area in the gastrointestinal mucosal epithelium and urogenital tract. Among neoplasms, villin is predominantly expressed in tumors of colorectal origin. Antibody to villin is useful in identifying malignant cells from primary and metastatic colorectal carcinomas. This antibody also labels Merkel cells of the skin.