Formalin-fixed, paraffin-embedded human Skin stained with TYRP1-Monospecific Mouse Monoclonal Antibody (TYRP1/3283).
SDS-PAGE Analysis Purified TYRP1-Monospecific Mouse Monoclonal Antibody (TYRP1/3283). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TYRP1-Monospecific Mouse Monoclonal Antibody (TYRP1/3283)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.