SDS-PAGE Analysis Purified TSH-Receptor, A-Chain Mouse Monoclonal Antibody (TSHRA/1402). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with TSHRA Mouse Monoclonal Antibody (TSHRA/1402).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.