TSHR Antibodies

The thyroid-stimulating hormone receptor (TSHR) is a membrane-bound receptor primarily expressed on the surface of thyroid follicular cells, which are the cells responsible for the production and secretion of thyroid hormones. The binding of TSH to TSHR on thyroid cells triggers a series of signaling events that stimulate the production and release of thyroid hormones (T3 and T4), a process that is essential for maintaining the balance of thyroid hormone levels in the body, which, in turn, is critical for proper metabolic function, growth, and development. In Graves’ disease, an autoimmune disorder is characterized by the production of autoantibodies that activate the thyroid-stimulating hormone receptor, there is excessive stimulation of the thyroid gland, and increased production of thyroid hormones.

Antibodies against TSHR are used in research to study the expression, structure and function of thyroid-stimulating hormone receptor in normal and pathological conditions. In clinical diagnostics, the measurement of anti-TSHR antibodies is used to aid in diagnosing autoimmune thyroid disorders, especially Graves’ disease.

Synonyms

Thyrotropin receptor, CHNG1|LGR3|hTSHR-I

Research Areas

Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors