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Home >> Antibodies >> Trefoil factor 2 / TFF2

Trefoil factor 2 / TFF2

Mouse Monoclonal Antibody [Clone GE16C]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
459.00
459.00

Product Details

Synonyms

SML1; SP; Spasmolysin; Spasmolytic polypeptide; TFF2; trefoil factor 2 (spasmolytic protein 1); Trefoil factor 2; Trefoil factor 2 precursor

Positive Control

Human stomach or duodenum tissues (IHC).

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA & Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Synthetic peptide corresponding to a 16-amino acid C-terminal sequence of the human Trefoil factor 2.

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgM, kappa

Mol. Weight of Antigen

14kDa

Specificity & Comments

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. pS2, also designated Md2, BCEI, TFF1 and pNR-2, is a trefoil protein that is highly expressed in normal gastric mucosa. pS2 has also been detected in a number of carcinomas including cancers of the breast, pancreas and stomach. pS2 is not present in normal breast tissue but is inducible by estrogen in MCF7 cells. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. The gene encoding pS2 maps to human chromosome 21q22.3.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nam et al. 2012. Lab Invest. 92(6):883-95.

Bioinformatics

  •  Entrez Gene ID: 7032
  •  Gene Symbol: TFF2
  •  SwissProt: Q03403
  •  Chromosome Location: 21q22.3
  •  Unigene: 2979
NBT03060