SDS-PAGE Analysis Purified SPTBN2 Recombinant Mouse Monoclonal Antibody (rSPTBN2/1778). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human HeLa cell lysate using SPTBN2 Recombinant Mouse Monoclonal Antibody (rSPTBN2/1778).
Analysis of Protein Array containing more than 19,000 full-length human proteins using SPTBN2 Monospecific Recombinant Mouse Monoclonal Antibody (rSPTBN2/1778).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.