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Home >> Antibodies >> RAD51 (Prognostic and Response to Chemotherapy Marker)

RAD51 (Prognostic and Response to Chemotherapy Marker)

Mouse Monoclonal Antibody [Clone RAD51/2765]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Analysis of Protein Array containing more than 19,000 full-length human proteins using RAD51 Mouse Monoclonal Antibody (RAD51/2765)

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SDS-PAGE Analysis Purified RAD51 Mouse Monoclonal Antibody (RAD51/2765. Confirmation of Purity and Integrity of Antibody

Product Details

Synonyms

RCA1/BRCA2 containing complex, subunit 5; BRCC5; DNA repair protein RAD51; FANCR; HsT16930; MRMV2; RAD51; RAD51 recombinase; RAD51A; RECA; RecA like protein; Recombination protein A

Positive Control

HeLa or MCF-7 cells. Colon or breast Carcinoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

37kDa

Specificity & Comments

RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies.RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Henning W, Stuerzbecher H-W (2003) Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 193: 91-109

Bioinformatics

  •  Entrez Gene ID: 5888
  •  Gene Symbol: RAD51
  •  SwissProt: Q06609
  •  Chromosome Location: 15q15.1
  •  Unigene: 631709
NBT02765